The Elder Scrolls 4: Oblivion

1. If you're farming for money, just come back to the place you just killed things and take them off when you can carry them.
2. If you're collecting things, get a house and put them in a container of some sort (they carry infinite). Also, if there is enough, sort them out.
3. Locked chests have the most expensive things, whether in a cave or not. So picking is very important.

Titan Quest

1. Explore all of the areas.
2. Kill all the monsters.
3. Do all the side quests as you play the game.

Pokemon

1. Level your starter to Lvl. 10 in the first route.
2. Catch a flying type as soon as you can.
3. If you can't beat the Elite/Gym leader/trainer, just fight them over and over again.
4. Beat all the trainers.
5. If you're almost dead (or are) and there is no way to heal, but there is a PC nearby just switch the Pokemon in and out of the PC, it heals them completely!